Mechanism of Photoreactivation of Pseudorabies Virus

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Characteristics of the photoreactivation of pseudorabies virus.

Pfefferkorn, E. R. (Harvard Medical School, Boston, Mass.), Boyce W. Burge, and Helen M. Coady. Characteristics of the photoreactivation of pseudorabies virus. J. Bacteriol. 92:856-861. 1966.-Pseudorabies virus, killed with ultraviolet light and then allowed to adsorb to chick embryo tissue culture cells, can be photoreactivated by light of longer wavelengths. The photoreactivable sector is app...

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Photoreactivation of a cytoplasmic virus.

Ultraviolet light-inactivated frog virus 3 is efficiently photoreactivated by chick embryo cells. A cellular enzyme is presumably responsible for this repair of viral deoxyribonucleic acid, for the phenomenon is insensitive to an inhibitor of protein synthesis and is not seen in mammalian cells that are known to lack photoreactivating enzyme. Since frog virus 3 is a cytoplasmic virus, functiona...

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Cultivation of Pseudorabies Virus

Pseudorabies virus has been cultivated in series in rabbit testicle, guinea pig testicle, and chick embryo media, and its growth requirements have been studied. Intranuclear inclusions, similar to those produced by pseudorabies virus in vivo, have been found in rabbit testicle cultures. The virus has not changed its pathogenic properties for rabbits, guinea pigs, or mice during the course of cu...

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Pseudorabies Virus

Etiology • Pseudorabies virus (PRV) is an enveloped, double-stranded DNA virus belonging to the family Herpesviridae. Also known as suid herpesvirus-1 (SuHV-1), the virus causes Aujeszky’s disease. • ‘Classical’ PRV strains affecting multiple species were first isolated in the early 1900s. ‘Variant’ PRV strains emerged in swine in China in 2011. • Genomic sequencing and phylogenetic analyses ha...

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Pseudorabies Virus

Etiology • Pseudorabies virus (PRV) is an enveloped, double-stranded DNA virus belonging to the family Herpesviridae. Also known as suid herpesvirus-1 (SuHV-1), the virus causes Aujeszky’s disease. • ‘Classical’ PRV strains affecting multiple species were first isolated in the early 1900s. ‘Variant’ PRV strains emerged in swine in China in 2011. • Genomic sequencing and phylogenetic analyses ha...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1968

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.2.5.474-479.1968